At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs, but few options.

Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine, and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visitneurocrine.com, and follow the company on LinkedIn, X (Formerly Twitter) and Facebook. (*in collaboration with AbbVie)

About the Role:

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• Proficiency in immunohistology techniques and tissue processing:

• Prepares and produces microscopic slides of various tissue (Cryosectioning, fixation, embedding, sectioning, and mounting). Expert in immunostains (IHC, ICC, IF), perform antibody/target validation of therapeutics. Experience operating cryostat machine

• Experience in maintaining sterile tissue culture environments in the expansion of multiple cell lines, human primary iPSC and immune cells, and culture of primary mouse neuronal and glial cells

• Execute cell-based assays related to inflammation and neurodegeneration, such as cytokine detection with MSD, luminescent cell viability, Nitric Oxide detection, ELISA, and Flow Cytometry.

• Functional cell assays, biochemistry, and high content imaging techniques

• Process to target validation, analyze pathology stage with cell and tissue expression by RNA, Western Blotting and IHC

• Rodent in vivo experiments: breeding, animal handling, test article dosing via various administration routes (PO, IP, SC, IV), behavioral monitoring, data collection, as well as data interpretation/analysis

• Performing perfusion, necropsy, dissections and tissue collection

• Assist with behavioral assay/model development

• Present data at internal group/team meetings

• Efficiently managing scheduling of studies, and managing own time to complete assigned work by due dates

• Exhibit strong adherence to standard operating procedures (SOPs) and protocols, maintaining accurate records of experimental procedures and results

• Assisting in other related procedures as assigned by the supervisor

• Data analysis and reporting

• Handle and dose animals in a laboratory setting

• Other duties as assigned

• BS/BA degree in biological sciences preferably related to neuroscience, immunology or pharmacology and some experience with cell culture and handling and dosing animals in a laboratory setting OR

• MS/MA degree in biological sciences preferably related to neuroscience, immunology or pharmacology and some experience with cell culture and handling and dosing animals in a laboratory setting

• Experience culture cell lines and human primary cells

• Experience in biochemistry assays and strong knowledge of immunohistology techniques

• Experience in handling rodents and general familiarity with behavioral analysis

• Experience with in vivo pharmacology and efficacy studies including multiple dosing routes of administration and necropsy procedures

• Can independently manage and troubleshoot rodent studies for in vivo endpoints

• Proficient in Microsoft Office (Outlook, Excel, PowerPoint), as well as some basic graphical and/or statistical software (e.g., Prism, Spotfire, JMP, etc.)

• Superior attention to detail, punctual, flexible, and an outstanding team-player who is comfortable working on and prioritizing multiple projects

• Able to execute experiments efficiently and suggest small process improvements

• Able to recognize patterns or inconsistencies in data results

• Able to deduce meaningful results while conducting routine analyses or troubleshoot minor issues. Good knowledge of one scientific discipline

• Developing knowledge of scientific principles, methods and techniques

• Good knowledge and some experience working with discipline specific laboratory equipment/tools

• Good computer skills

• Developing communications, problem-solving, analytical thinking, planning and organization skills

• Understands importance of meeting deadlines

• High level of organization and attention to detail

• Willingness and ability to work both independently and as part of a team

Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.

We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description.

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